Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression

CG Davey; S Whittle; BJ Harrison; JG Simmons; ML Byrne; OS Schwartz; NB Allen

Journal article

Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression

CG Davey, S Whittle, BJ Harrison, JG Simmons, ML Byrne, OS Schwartz, NB Allen

Psychological Medicine | Published : 2015

DOI: 10.1017/S0033291714002001

Abstract

Background. The amygdala and subgenual anterior cingulate cortex (sACC) are key brain regions for the generation of negative affect. In this longitudinal fMRI study of adolescents we investigated how amygdala-sACC connectivity was correlated with negative affectivity (NA) both cross-sectionally and longitudinally, and examined its relationship to the onset of first-episode depression. Method. Fifty-six adolescents who were part of a larger longitudinal study of adolescent development were included. They had no history of mental illness at the time of their baseline scan (mean age 16.5 years) and had a follow-up scan 2 years later (mean age 18.8 years). We used resting-state functional-connec..

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University of Melbourne Researchers

Chris Davey Author

Sarah Whittle Author

Ben Harrison Author

Julian Simmons Author

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Grants

Awarded by National Health and Medical Research Council

Awarded by Australian Research Council

Awarded by National Health and Medical Research Fellowships

Funding Acknowledgements

The research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (Program Grant 350241), and the Australian Research Council (Discovery Grant DP0878136). Drs Davey, Whittle and Harrison are supported by National Health and Medical Research Fellowships (IDs 628509, 1007716 and 628509).